The functional consequences of the c.42-1060_-1057dupTTGA polymorphism might also modulate the risk of venous thrombosis in patients with other genetic defect causing antithrombin deficiency, as it has recently described for antithrombin Cambridge variants, a relatively frequent variation of SERPINC1 [31].Finally, the potential role in thrombosis of this new polymorphism should be evaluated in large case/control studies. The gene discussed is SERPINC1; the disease is hereditary antithrombin deficiency.