LEPR and obesity due to melanocortin 4 receptor deficiency: We created a unique model of obesity by deriving whole-body LepR-deficient (Ubc-CreERT2LepRloxP/loxP; LepR-knockout [KO]) mice on a B6.129 F1 hybrid background, resulting in tamoxifen-induced LepR gene deletion (ESM Fig. 1).