Subsequent elevation of the genes encoding the inflammatory chemokines such as CCL16, CCL25 and CXCL6, and cytokines such as IL-2, IL-8 and IFNG (Fig 4) in concert with delayed activation of the coagulation system (Fig 2) are the typical signatures of sepsis [36] [37]. The gene discussed is CXCL8; the disease is Sepsis.