PUDP and cancer: Haloacid Dehalogenase-like Hydrolase domain-containing 1 (HDHD1) dephosphorylates pseudouridine 5′-phosphate, a modified RNA nucleotide present in tRNAs, rRNAs, and small nuclear RNAs; pseudouridine is excreted in urine and serves as a biomarker for certain cancers (25).