The AUROC analysis revealed that the AUROCs of both Fuc-Hpt and Mac-2 bp were sufficient to evaluate the fibrotic grade in patients with chronic hepatitis C and although neither the Fuc-Hpt nor Mac-2 bp levels exceeded the values of the known fibrotic markers, the usefulness of these markers was comparable with the known fibrotic markers, such as the FIB4 index or APRI. Here, MRS2 is linked to chronic hepatitis C virus infection.