Because the correlation coefficients between the Fuc-Hpt or Mac-2 bp levels and the FIB4 index and APRI were weak, it encouraged us to examine the usefulness of the combination of the Fuc-Hpt or Mac-2 bp levels with the known fibrotic markers, such as the FIB4 index or APRI, in evaluating liver fibrosis. The gene discussed is MRS2; the disease is Hepatic fibrosis.