PPARG and metabolic dysfunction-associated steatotic liver disease: This finding correlates with our previous data demonstrating that hypermethylation at the same PPARγ promoter DMRs in liver biopsy tissues can be used to identify patients who had progressed to Kleiner grade 3–4.21 While our study used only a relatively low number of patient samples (26 NAFLD and 13 ALD), the fact that PPARγ promoter hypermethylation correlated with disease progression across two distinct disease aetiologies is encouraging and supportive of further studies on the diagnostic and prognostic utility of PPARγ DMRs and indeed other genomic DMRs.