Noteworthy is a recent cell-specific knockout study reporting that hepatocyte PPARγ1 mRNA is highly suppressed after experimental induction of liver fibrosis in mice.31 Experimentally, the loss of PPARγ expression in hepatocytes has been implicated as a signal for HSC preactivation and accelerated fibrogenesis32; such a process may constitute an important cross-talk mechanism between hepatocytes and HSCs that drives disease progression to fibrosis and cirrhosis. The gene discussed is PPARG; the disease is Cirrhosis.