GLI3 and neoplasm: We found that expression of miR-378a-3p decreased but expression of gli3 mRNA increased in tumour compared with non-tumour tissues from each HCC sample, demonstrating the correlation of expressional regulation between miR-378a-3p and gli3. In addition, levels of the miR-378 family were also low in injured livers of mice fed for 3 or 4 weeks on an MCDE diet.