In conclusion, our study demonstrates that miR-378a-3p suppresses the activation of HSCs by targeting gli3, and that Hh-responsive Smo represses the transcriptional expression of miR-378a-3p through p65, promoting the activation of Hh and profibrotic genes by increasing the expression of the Hh target genes, Gli2 and Gli3, during liver fibrosis. The gene discussed is SMO; the disease is Hepatic fibrosis.