IL37 and infection: Furthermore, recombinant human IL-37 injected intraperitoneally into mice markedly reduced NLRP3-dependent neutrophil recruitment and IL-1β production and mitigated lung inflammation and damage in response to intranasal infection with live Aspergillus fumigatus conidia suggesting that IL-37 functions as a broad spectrum inhibitor of the innate response to infection-mediated inflammation [201].