IL37 and colitis: IL-37 transgenic mice also exhibited reduced clinical disease scores and histological evidence of colitis in the DSS model of induced colitis [197], suppressed contact hypersensitivity in response to hapten antigen 2,4-dinitrofluorobenzene by inducing tolerogenic dendritic cells [198] and are protected from myocardial and hepatic ischemic damage [199, 200].