Reducing IL-18 activity using IL-18 vaccination, IL-18 neutralising antibodies, IL-18BP, or performing experiments in IL-18 deficient mice has been shown to reduce disease severity in a number of animal models including dextran sulphate sodium (DSS)-induced colitis [167, 168], collagen-induced arthritis [169, 170] and allergic airway hyperresponsiveness [171]. Here, IL18 is linked to colitis.