ITGA6 and breast carcinoma: A similar reduction in percentage of cells staining positive for CD49f-FITC in response to deletion of both HIFα subunits was also observed in MCF-7 cells, a luminal model of breast cancer in which ~10 % of all cells express CD49f [15] (~3-fold decrease for shControl vs. DKD cells; Additional file 2: Figure S2).