We found that young age, fever duration ≥3days, tachypnea, tachycardia, hypertension, capillary refill time (CRT) >2 s, hyperglycaemia, leucocytosis, C-reactive protein (CRP) ≥40 mg/L, myoclonus, vomiting, coma, limb weakness, drowsiness and ANS involement were significant risk factors for cardiopulmonary failure. This evidence concerns the gene CRP and Hypertension.