In addition, we found that tachypnea, hypertension, CRT >2 s, and CRP ≥40 mg/L were also risk factors; and among the above factors, our results revealed that young age, fever duration ≥3 days, coma, limb weakness, drowsiness and ANS involvement were more significantly associated with cardiopulmonary failure. This evidence concerns the gene CRP and hypertensive disorder.