Using CE-MS, 12 urinary biomarkers for PCa, including sodium/potassium-transporting ATPase γ, collagen α-1(III), collagen α-1(I), psoriasis susceptibility 1 candidate gene 2 protein, hepatocellular carcinoma associated protein TB6, histone H2B, osteopontin, polymeric Ig receptor, transmembrane secretory component, prostatic acid phosphatase, fibrinogen α chain precursor, and semenogelin 1, were identified and validated (91 % sensitivity and 69 % specificity) [104]. Here, SPP1 is linked to posterior cortical atrophy.