BAX and leukemia: In addition to Yap1’s function as an oncogene, it can induce apoptosis by associating with p73, a functional homolog of p53, and up-regulate the expression of pro-apoptotic genes, such as Bcl2-associated X protein (Bax) and promyelocytic leukemia (PML) (Basu et al., 2003; Lapi et al., 2008; Zhang et al., 2011).