CST3 and Abnormal renal physiology: In our study eGFR was estimated using serum creatinine which is different from cystatin C method utilized by Esezobor et al. Dondo et al in study conducted among HIV infected children in Zimbabwe reported renal dysfunction (defined by eGFR of 30 to ≤ 90 ml/min/1.73 m2) in 34.6 % of participants [6].