While other studies have reported the dysregulation of some Gtl2-Dio3 miRNAs in cardiac disease models including myocardial infarction [21–24], these studies did not analyze expression of Gtl2-Dio3 miRNAs in models of chronic cardiotoxic insult (Ang II), dystrophic cardiomyopathies (mdx, DyW), or in the temporal progression of myocardial infarction (MI). The gene discussed is MEG3; the disease is myocardial infarction.