MEG3 and cardiac hypertrophy: To determine whether the Gtl2-Dio3 noncoding RNAs are regulated in response to pathological cardiac hypertrophy induced by a chronic neurohormonal insult, we also examined the expression of these transcripts 3-, 7-, and 14-days after administration of angiotensin II (Ang II), a potent cardiotoxic hormone that promotes extensive myocardial hypertrophy and fibrosis [19].