Kaiso is highly expressed in several TNBC cell lines (our unpublished data) and nuclear Kaiso expression has been linked with EMT and TNBC aggressiveness.20, 29 To determine the clinical relevance of Kaiso (ZBTB33) expression in aggressive BCa, we analyzed The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) (GSE20685) breast cancer data sets. The gene discussed is ZBTB33; the disease is breast cancer.