VIM and breast neoplasm: As our in vitro studies showed that Kaiso-depleted cells underwent mesenchymal-to-epithelial transition and exhibited a more epithelial phenotype (that is, increased E-cadherin and ZO-1 but decreased Slug, ZEB1 and Vimentin expression), the effect of Kaiso depletion on the metastatic potential of breast tumor cells may be partially attributed to the attenuated EMT phenotype observed in these cells.