NORE1A (RASSF5), the other major RASSF family member, is also frequently inactivated in human cancers [8] and serves as a Ras effector connecting Ras to the Hippo pathway [18], is a key mediator of Ras-induced senescence [19,20], and links Ras to the control of protein stability [21]. Here, RASSF5 is linked to cancer.