ACE and angioedema: The inhibition of ACE-1 is a favoured strategy in treating hypertension [101] and several synthetic ACE inhibitors (captopril, lisinopril, enalapril and fosinopril) are thus used for this reason in the treatment of hypertension [102] Despite their effectiveness, synthetic ACE inhibitors are responsible for a number of unpleasant side effects such as development of a cough, loss of taste, renal impairment, and angioneurotic oedema and as a consequence there has been a trend recently to explore and develop more natural inhibitors of ACE activity [88].