Additionally, the rs762623 variant in the promoter region of Cyclin-dependent Kinase 1A (CDKN1A) gene, encoding for p21 protein, was associated with the development but not the progression of fibrosis in NAFLD independently from well-recognized PNPLA3 I148M status [72]. The gene discussed is CDKN1A; the disease is metabolic dysfunction-associated steatotic liver disease.