Nevertheless, Cdr1as-induced effects could all be reversed by the overexpression of miR-7a through the co-transfection of lentivirus with miR-7a mimic (Fig 6), supporting that miR-7a could protect cardiomyocytes from Cdr1as-induced aggravation of MI injuries, involving the re-downregulated expression of PARP and SP1. Here, SP1 is linked to myocardial infarction.