Post hoc analysis of HLA-DPA1 showed downregulation of HLA-DPA1 mRNA in the ACC of bipolar disorder patients relative to healthy control subjects using the Affymetrix Human Exon 1.0 ST array data (GEO Accession Number: GSE78246) (Table 4) along the entire length of the gene (Figure 2A). This evidence concerns the gene HLA-DPA1 and bipolar disorder.