At the time the mice were killed, we found that RG7388 treatment significantly suppresses p53 wild-type neuroblastoma xenograft tumor growth by 59% in NGP (P=0.003), 67% in SH-SY5Y (P=0.006), and 75% in LAN-5 (P=0.0019) as compared with vehicle-treated mice (Figure 3b). This evidence concerns the gene TP53 and neuroblastoma.