RT-PCR based studies on CYP1B1 expression have reported its constitutive expression in many fetal tissues, including brain, adrenal glands, liver and kidneys in the first and second trimesters.2 The expression of this gene almost ubiquitously in fetal tissues and anatomical compartments implies its importance in development and advocates its involvement in developmentally important disease which includes primary congenital glaucoma (PCG). Here, CYP1B1 is linked to primary congenital glaucoma.