LDLR and glaucoma: The discovery of over-expression of LDL-receptors in activated Tenon's capsule fibroblasts106 has led to research on of LDL-chitosan nanoparticles incorporated with MMC as a method of allowing safe and sustained release of MMC following glaucoma surgery.107 This approach could potentially allow more targeted delivery of MMC as MMC is confined and protected by the chitosan nanoparticles until the particles bind to the over-expressed LDL receptors on Tenon's fibroblasts and then released.