This plasticity is now used in the treatment of cancer, as immunotherapy using monoclonal antibodies (e.g., anti-OX40, anti-EMMPRIN) was shown to modulate the microenvironment, reduce the levels of anti-inflammatory cytokines (e.g., TGFβ), change the T cell infiltrate, and repolarize macrophages to become M1-activated, capable of killing tumor cells [96, 97]. The gene discussed is TGFB1; the disease is neoplasm.