Lactate contributes to macrophage polarization by stabilizing HIF-1α and inducing expression of typical M2-phenotype markers like VEGF and arginase-I (ARG-I) [59], so that tumor-associated macrophages (TAMs) sense the metabolic changes in tumor cells and respond to them in a proangiogenic manner [1]. The gene discussed is VEGFA; the disease is neoplasm.