TARDBP and amyotrophic lateral sclerosis: Indeed, iPSCs have been generated from ALS patients with mutations in SOD1 (Chestkov and Vasilieva, 2014, Dimos et al., 2008), TDP-43 (Bilican et al., 2012, Egawa et al., 2012), C9ORF72 (Almeida et al., 2013, Sareen et al., 2013) and recent publications of FUS (Lenzi et al., 2015, Liu et al., 2015, Di Salvio et al., 2015) suggest a useful tool for pursuing the cellular pathogenesis and mechanism underlying FALS.