IGF1 and glomerulosclerosis: Therefore, the relative increase in the mean glomerular and podocyte volume in GH‐transgenic mice, as compared to non‐GH‐transgenic mice of the same Igf1 status appears to be a critical step in the development of glomerulosclerosis in GH‐transgenic murine nephropathy models, rather than excess of a distinct absolute glomerular or podocyte size.