CD4 and dengue disease: In mammals, as well as interacting with each other to potentiate Th2 responses through APC–Th2 CD4 T‐cell interactions, TIM1 and TIM4 bind PS and mediate the entry of enveloped viruses such as Ebola33, 34 and dengue,35 and in PS‐mediated phagocytic engulfment and removal of apoptotic cells.35 The chTIM4 bound strongly to PS, weakly to PE, and did not bind to PC, PI or the negative control (PBS) in a dot blot assay (Fig. 8a).