In the remaining patients whose antibodies did not bind to the neurons or to LGI1, the VGKC‐complex Abs may be markers for a neuroinflammatory process rather than for an antibody‐mediated syndrome, as recently discussed.12, 22, 26 Surprisingly, therefore, antibodies to CASPR2 or contactin‐2, the other known components of the VGKC complex, were found in 11 pediatric epilepsy patients (seven at onset, four during follow‐up), but not in controls. Here, LGI1 is linked to epilepsy.