Since CD34+ hematopoietic stem cell (HSC)-transplanted NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) mouse is the simplest and most accessible model for the studies of viral infection compared to the complexities of transplanting human liver and thymic tissues with autologous CD34+ HSC needed to generate BLT mice, we took advantage of CD34-NSG model for the investigation of viral distribution in tissues and sorted cell populations to define virus-cell interactions. Here, CD34 is linked to viral infectious disease.