Among single nucleotide polymorphisms (SNPs) in SORL1, Rogaeva et al.3 observed a substantial association between a synonymous SNP in exon 34 (rs3824968) and AD in a northern European case–control cohort and implied that the SNP alters the physiological role of SORL1 in the processing of APP holoprotein. The gene discussed is SORL1; the disease is Alzheimer disease.