In addition to a previous study, which proposed a pathway by which SORL1 variants could mediated neural risk of AD beginning from teenage years25, current data support two pathways of SORL1 rs3824968 effect on GM volume during the ageing process: (1) differences of regional cortical volume between the three genotypes occur from early adult life and preferentially stay stable during adulthood and (2) in contrast to the first pathway, variants of SORL1 rs3824968 do not modulate putaminal volume directly but interact with age during the adult lifespan. Here, SORL1 is linked to Alzheimer disease.