However, in humans the persistence and maturation of these RNP granules via complex mechanisms leads to pathological protein accumulation and neurodegenerative disease (Fig. 2) (Guo and Shorter, 2015; Lin et al., 2015; Molliex et al., 2015; Murakami et al., 2015; Patel et al., 2015; Xiang et al., 2015). This evidence concerns the gene RNPC3 and neurodegenerative disease.