A low level of TEM8 expression 0.005 (0.000–0.054) was found in the control group including 18 cases of normal bone tissues, 10 cases of osteosblastoma, 10 cases of osteoma, 4 cases osteoid ostoma and 8 cases of tumor-like bone lesions (osteofibrous dysplasia and fibrous dysplasia Fig. 1A). The gene discussed is ANTXR1; the disease is neoplasm.