More importantly, adoptive transfer of CD8+ T lymphocytes from dnTGFβRII mice induces autoimmune cholangitis with prominent inflammatory cell infiltration, bile duct destruction, and granuloma formation in the portal tract in Rag-1−/− recipient mice, whereas transfer of CD4+ T cell did not induce PBC-like hepatic lesions42. Here, CD4 is linked to primary biliary cholangitis.