In C57BL/6 mice, Gal-3 deletion exacerbates the disease through significantly higher liver infiltrates of CD8+ T lymphocytes, with enhanced bile duct damage, liver fibrosis, serological level of PDC-E2 specific IgA and increased AST/ALT ratio (Figs 2 and 3). The gene discussed is DLAT; the disease is Hepatic fibrosis.