Therefore, insulin deficiency promotes a clinical deterioration in this population and not only an abnormal glucose metabolism, which may be enhanced by early intervention with insulin.6 Both diabetes and glucose intolerance reduce the life expectancy of CF patients; insulin is the only treatment that improves clinical outcomes.8 Early treatment with insulin may reduce the morbidity and mortality of the underlying disease.9,10. The gene discussed is INS; the disease is Glucose intolerance.