GNA11 and uveal melanoma: In contrast to germline gain-of-function Gα11 mutations, which affect Ca2+o homeostasis, somatic gain-of-function Gα11 mutations have been reported to lead to uveal melanoma, which is a primary intraocular tumor, by inducing constitutive up-regulation of proliferative signaling involving ERK, which is a component of the MAPK signaling pathway (11).