GNA11 and uveal melanoma: The objective of this study was to undertake in vitro studies to determine whether allosteric modulators targeted to the CaSR may also rectify the loss- and gain-of-function associated with FHH2- and ADH2-causing germline Gα11 mutations, respectively, and the up-regulation of ERK phosphorylation caused by a uveal melanoma-associated somatic Gα11 mutation.