GNRH1 and hypogonadism: Other developmental pleiotropic diseases such as the CHARGE syndrome, trisomy 13 or Patau syndrome, and trisomy 18 or Edward syndrome in which the OB is hypoplasic or aplasic also show migration defects in GnRH neurons [253], which leads to a decrease in the levels of circulating sex hormones causing hypogonadism in these patients.