The following results identified Slug as a functional target of miR-630 in HCC cells: (1) Slug expression in HCC tissues was inversely correlated with miR-630 expression; (2) ectopic expression of miR-630 reduced Slug levels significantly in HCC cells, whereas inhibition of miR-630 contributed the opposite effect (3) ectopic expression of miR-630 reduced the activity of a luciferase reporter fused to the WT, but not the MUT 3′-UTR of Slug. Here, SNAI2 is linked to hepatocellular carcinoma.