NPM1 also plays important roles in cancer since it is over-expressed in proliferating cells compared to normal cells [17, 18] and has been proposed to be a marker of different solid tumors such as prostate [19], colon [20], ovarian [21], gastric [22], bladder [23], hepatomic [24], oral [25] and thyroid [26, 27] carcinomas. This evidence concerns the gene NPM1 and cancer.