AR and posterior cortical atrophy: It is noteworthy to mention that certain PCa cells have the capacity to transdifferentiate to acquire a neuroendocrine (NE) like phenotype which has been proposed as a mechanism for chemo and castration resistances [35] Moreover, there has been increasing concerns that with the introduction of novel potent AR-targeted drugs into the clinic for CRPC, the incidence of Neuroendocrine PC (NEPC) may increase [47].