Discovery and validation of a distinct set of sensitive and specific biomarkers for risk-stratifying patients at high risk for developing PDAC would eventually enable routine screening of high risk groups (i.e., incidental detection of pancreatic lesions, family history of PDAC, hereditary syndromes (VHL), chronic pancreatitis, type 3c diabetes, smokers, BRCA2 carriers, etc). Here, BRCA2 is linked to von Hippel-Lindau disease.