SERPINB5 and pancreatic intraductal papillary-mucinous neoplasm: TMPRSS4, SERPINB5, ECT2, and AHNAK2 are overexpressed in LIGD-IPMN, HGD-IPMN, and InvCa-IPMN as well as in PanINs, as compared to normal pancreas, demonstrating that enhanced expression of multiple genes linked to metastasis and PDAC progression occurs early on during malignant development.