EGFR and non-small cell lung carcinoma: Therefore the current treatment options available in second-line treatment include docetaxel, pemetrexed, and the EGFR-TKI erlotinib, which is the only one approved also as third-line therapy, as highlighted by the BR.21 study, first showing a clinical benefit of erlotinib over placebo in a pre-treated and unselected NSCLC population [18].