Large scale melanoma genomic studies listed in cBioPortal [22, 23] have shown somatic missense mutations of RASA1 in 2 out of 121 patients (P135S and E510K) [24], 1 of 91 (R245H) [8], and 3 of 228 (P130L, K468N, S509N, and R913Q) [25] (Figure 1A). Here, RASA1 is linked to melanoma.