A haplotype at the IKZF3/ORMDL3 locus is associated with primary biliary cirrhosis, systemic lupus erythematosus, systemic sclerosis, Type 1 diabetes autoantibodies, type 1 diabetes, ulcerative colitis, Crohn’s disease, inflammatory bowel disease and rheumatoid arthritis (Hindorff et al. 2011) (Fig. 3c and Fig. S2 in Supplementary material 1). Here, ORMDL3 is linked to primary biliary cholangitis.