A haplotype at the IKZF3/ORMDL3 locus is associated with primary biliary cirrhosis, systemic lupus erythematosus, systemic sclerosis, Type 1 diabetes autoantibodies, type 1 diabetes, ulcerative colitis, Crohn’s disease, inflammatory bowel disease and rheumatoid arthritis (Hindorff et al. 2011) (Fig. 3c and Fig. S2 in Supplementary material 1). This evidence concerns the gene IKZF3 and systemic sclerosis.