COG6 and psoriasis: Purified B cells from blood donors, homozygous, CC or GG, for the alleles at rs9603612 were stimulated with ODN2216 and we determined the expression of the psoriasis candidate gene COG6. A donor homozygous for the G allele had significantly higher expression than the one homozygous for C. In the cells stimulated with ODN2216, the expression of COG6 increased significantly for both genotypes (Fig. 4c, lower panel).