Prognostic factors included in the univariate analysis were as follows: age, gender, tumor size (cT1-2 vs. cT3-4), smoking, alcohol use, nodal stage (cN0 vs. cN+), number of intratumor CD3+, CD8+, and CD4+ cells, SERPINB9 staining (positive vs. negative), SERPINB1 staining (high vs. low expression), and SERPINB4 staining (H-score high vs. low expression). This evidence concerns the gene SERPINB4 and neoplasm.