APOE and Alzheimer disease: In the subset of individuals with either biomarker (CSF or amyloid PET) or pathologic evidence for underlying AD (n = 82), rs2075650 (at the APOE/TOMM40 locus, subsequently referred to as APOE) was again identified as a risk factor with a similar OR to the whole group (OR = 2.00 [1.39–2.89] P = 9 × 10−5, PGC = 1 × 10−4).