INPP5D and Alzheimer disease: Although they did not confer significant alteration of PCA risk, we found that odds ratio confidence intervals for SNPs at or near to INPP5D and NME8 in PCA did not overlap those of typical AD and showed directionally opposite effects, INPP5D was identified as a risk factor for AD in a recent large meta-analysis and plays an important role in a number of inflammatory processes.