To gain insight into the mechanism of Aβ-induced BACE1 elevation in peri-plaque dystrophies and the potential role of microtubules, we performed immunofluorescence staining of superior temporal gyrus from AD patients and cognitively normal controls (Table S2) with antibodies against BACE1 and neuron-specific βIII-tubulin, as well as methoxy XO4 to label fibrillar amyloid deposits. Here, BACE1 is linked to Alzheimer disease.