TARDBP and frontotemporal dementia: Postmortem studies revealed that the most common pathology affecting the semantic variant is ubiquitin/TDP43-positive frontotemporal lobar degeneration, which is characterized by numerous dystrophic neurites associated with neuronal and synaptic loss.10 It is therefore most likely that diffusivity abnormalities in the uncinate fasciculus reflect axonal degeneration of the white matter fibers secondary to the cortical pathology.