The somatic transitions C228T and C250T in the TERT promoter do not only occur in melanoma, but strikingly in numerous malignancies such as hepatocellular carcinoma (HCC) and are among the most frequent mutations in cancer (Vinagre et al, 2013; Totoki et al, 2014; Weinhold et al, 2014; Melton et al, 2015). This evidence concerns the gene TERT and hepatocellular carcinoma.