PNPLA8 and Weaver syndrome: The corresponding CI (between 49,514,652 and 50,367,484 bp) contained two genes that were previously discussed by McClure et al. [23] as two of the most likely candidate genes for Weaver syndrome: NRCAM and PNPLA8, with PNPLA8 being more closely located to the position of the maximum LRT value (Fig. 1b).