Although the precise underlying mechanism by which MALL influences these cellular activities remains unknown, we showed that MALL overexpression in SW480 and HCT116 cells reduced the phosphorylation of ERK possibly through ESR1. This suggests that MALL suppresses tumor growth and metastasis through inhibiting the ERK MAPK pathway, which is consistent with previous studies showing that cell adhesion, angiogenesis, invasion, and metastasis in colorectal cancer could be induced by ERK activation. This evidence concerns the gene ESR1 and neoplasm.