This is further supported by the observation that miR-101 restoration leads to a decrease in H3K27me3 (a chromatin mark typically deposited by EZH2) at the promoter of the tumor suppressor p21 and to an increase in p21 transcription [113], which is in line with the re-expression of p21Waf1/Cip1 triggered by EZH2 downregulation in ovarian cancer cells [115]. The gene discussed is CDKN1A; the disease is ovarian carcinoma.