EZH2 and ovarian carcinoma: Apart from a role in embryonic development (reviewed by Gabory et al. [29]) through effects in cis on the igf2 gene and in trans on the imprinted gene network controlling growth in mice [30], H19 has been found to be associated with EZH2 [100] and to be overexpressed in many malignancies [16, 101] including ovarian carcinomas [102].